Isocyanates are reactive and versatile chemicals. During WW2 they were used to develop polyurethanes as an alternative to natural rubber. Since then isocyanate use has continued to grow and they now have widespread commercial and consumer applications. Isocyanates have known adverse health effects. The main effects of isocyanate exposure are occupational asthma and lung disease. Some isocyanates are carcinogenic.

Studies in the construction industry show up to 57% of spray foam workers demonstrate the effects of isocyanate exposure. Environmental exposure has been detected in residents living close to manufacturers employing isocyanates. Case studies associate families displaying symptoms of isocyanate exposure with home insulation. Other studies have shown the presence of isocyanates in medical devices and the exposure of neonatal infants – the effects of these exposures are unknown. There is a need for simple, rapid and cost-effective tests for monitoring human exposure to isocyanates.

The production of antibodies to isocyanate biomarkers will enable the development of new isocyanate biomonitoring tests. Immunoassays provided in ELISA format will allow the laboratory analysis of large sample numbers and the provision of routine test services. The development of point of care tests will enable on-site use and real time monitoring. Providing employers with immediate confirmation of good working practice and on the job reassurance to those involved in hazardous tasks.

If you would like to know more about our isocyanate biomonitoring programme then please contact us using the link below.


What products & services will Chemitrace offer for isocyanate biomonitoring?